Star Trek fans will recognize her as Star Trek: Deep Space Nine's fundamentalist Kai Winn/Vedek Winn in 14 episodes. She also appeared in the science fiction anthology series The Twilight Zone and Ray Bradbury Theater.
On the big screen, Fletcher appeared in Doug Trumbull's Brainstorm (1983), the Stephen King adaptation Firestarter (1984), and Tobe Hooper and Dan O'Bannon's Invaders from Mars (1986).